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KMID : 1007520090180041019
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Food Science and Biotechnology
2009 Volume.18 No. 4 p.1019 ~ p.1021
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Atractylodes japonica Rhizome Inhibits Cell Proliferation and Induces Apoptosis in vitro
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Choi Eun-Jeong
Kim Gun-Hee
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Abstract
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Antiproliferative activity of the ethanol extract of Atractylodes japonica rhizomes (AJEX) was investigated usingmethyl thiazolyl tetrazolium (MTT) assays with various cancer cell lines (HL-60, MCF-7, SK-Br-3, MDA-MB-453, HepG2,Hep3B, PC-3, LNCaP, MKN 28, MKN 45, and HT-29 cells). Gastric carcinoma cell lines were the most responsive in termsof cell proliferation. The IC50 of MKN 28 and MKN 45 cells were 35.98 and 27.57μg/mL, respectively. Moreover, gastriccarcinoma cells exposed to AJEX underwent apoptosis, as determined by Annexin V binding assay. Compared to respectivecontrol level, exposure to the AJEX at each IC50 concentration resulted in a remarkable increase in the shift of cellpopulations. Present results suggest that AJEX possess potential anticancer properties.
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KEYWORD
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Atractylodes japonica, apoptosis, cell proliferation, in vitro, IC50
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